Alsiano supplies a range of fillers sourced from leading manufacturers. Many of the fillers also provide various properties or functionalities such as being free-flowing powders, offering low hygroscopicity, functioning also as binders and disintegrants, and promoting processing stability. See more below and feel free to contact us for more information about specific products and for special requests.
Calcium phosphate and calcium carbonate are excellent fillers or diluents for oral solid dosage forms and contribute also with other functionalities such as binding.
Calcium phosphate is a popular excipient and is widely used in solid oral dosage forms as a filler and as a binder. It has excellent flowability and compressibility characteristics. In addition, it is relatively low cost. Alsiano offers Dibasic calcium phosphate (DCP) and Tricalcium phosphate (TCP).
DCP has excellent flow properties and is great for direct compression tableting formulation. Particle size, bulk and tapped density can be varied to suit customer requirement. Available as dihydrate and anhydrous.
TCP is a bulky powder with an ideal Ca/P ratio of 2:1 for better bioavailability in calcium supplements. The TCP is manufactured by a special process giving it high porosity, making it also great for application as an anticaking agent.
Both types of calcium phosphate are BP/EP/USP/FCC.
The Destab™ calcium carbonate range is pre-granulated in bulk using carriers such as starch, acacia gum, or maltodextrin. Destab™ calcium carbonate is perfect for direct compression tablets and capsules. The materials are granular, free flowering powders, extremely consistent in particle size. Superior consistency throughout each lot allows for operating equipment at higher speeds with greater efficiencies.
These calcium carbonates bring excellent compressibility and disintegration properties which improve tablet performance. Optimal particle property is another advantage which improve tablet press speeds and reduce manufacturing costs. Furthermore, the excellent flow properties of the material will prevent blockage and improve yields in high-speed tablet processes.
The high-quality calcium carbonate also includes ultra-low lead products (no more than 250 ppb).
Lene Aarøe Nissen
Head of Nordic Sales
+45 22 70 10 02